Being pregnant while young is known to protect a women against breast cancer. But why? Research in BioMed Central's open access journalBreast Cancer Research finds that Wnt/Notch signalling ratio is decreased in the breast tissue of mice which have given birth, compared to virgin mice of the same age.
Early pregnancy is protective against breast cancer in humans and in rodents. In humans having a child before the age of 20 decreases risk of breast cancer by half. Using microarray analysis researchers from Basel discovered that genes involved in the immune system and differentiation were up-regulated after pregnancy while the activity of genes coding for growth factors was reduced.
The activity of one particular gene Wnt4 was also down-regulated after pregnancy. The protein from this gene (Wnt4) is a feminising protein - absence of this protein propels a foetus towards developing as a boy. Wnt and Notch are opposing components of a system which controls cellular fate within an organism and when the team looked at Notch they found that genes regulated by notch were up-regulated, Notch-stimulating proteins up-regulated and Notch-inhibiting proteins down-regulated.
Wnt/Notch signalling ratio was permanently altered in the basal stem/progenitor cells of mammary tissue of mice by pregnancy. Mohamed Bentires-Alj from the Friedrich Miescher Institute for Biomedical Research, who led this study explained, "The down-regulation of Wnt is the opposite of that seen in many cancers, and this tightened control of Wnt/Notch after pregnancy may be preventing the runaway growth present in cancer."
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Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium
Fabienne Meier-Abt, Emanuela Milani, Tim Roloff, Heike Brinkhaus, Stephan Duss, Dominique S Meyer, Ina Klebba, Piotr J Balwierz, Erik van Nimwegen and Mohamed Bentires-Alj
Breast Cancer Research (in press)
BioMed Central: http://www.biomedcentral.com
Thanks to BioMed Central for this article.
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FORT COLLINS, Colo. (AP) ? Fort Collins police say they used tear gas to disperse a large and noisy street party near the Colorado State University campus as some revelers threw bottles at officers.
Police spokeswoman Rita Davis says officers were called to the Summerhill neighborhood late Saturday night amid complaints of a gathering that drew about 300 partygoers.
She says in a news release that officers urged people to leave, but the crowd became unruly and began throwing bottles at police as well as climbing on cars, street light poles and trees.
Some media reports described the melee as riot-like.
Davis says that eventually, police used tear gas and pepper spray to disperse the crowd.
Three partygoers were treated at a hospital for minor injuries, but Davis says no officers were hurt.
The media reports say the event drew mainly a college-age crowd after it was advertised during the week via social media.
Contact: George Hunka ghunka@aftau.org 212-742-9070 American Friends of Tel Aviv University
Neurons in the nose could be the key to early, fast, and accurate diagnosis, says a Tel Aviv University researcher
A debilitating mental illness, schizophrenia can be difficult to diagnose. Because physiological evidence confirming the disease can only be gathered from the brain during an autopsy, mental health professionals have had to rely on a battery of psychological evaluations to diagnose their patients.
Now, Dr. Noam Shomron and Prof. Ruth Navon of Tel Aviv University's Sackler Faculty of Medicine, together with PhD student Eyal Mor from Dr. Shomron's lab and Prof. Akira Sawa of Johns Hopkins Hospital in Baltimore, Maryland, have discovered a method for physical diagnosis by collecting tissue from the nose through a simple biopsy. Surprisingly, collecting and sequencing neurons from the nose may lead to "more sure-fire" diagnostic capabilities than ever before, Dr. Shomron says.
This finding, which was reported in the journal Neurobiology of Disease, could not only lead to a more accurate diagnosis, it may also permit the crucial, early detection of the disease, giving rise to vastly improved treatment overall.
From the nose to diagnosis
Until now, biomarkers for schizophrenia had only been found in the neuron cells of the brain, which can't be collected before death. By that point it's obviously too late to do the patient any good, says Dr. Shomron. Instead, psychiatrists depend on psychological evaluations for diagnosis, including interviews with the patient and reports by family and friends.
For a solution to this diagnostic dilemma, the researchers turned to the olfactory system, which includes neurons located on the upper part of the inner nose. Researchers at Johns Hopkins University collected samples of olfactory neurons from patients diagnosed with schizophrenia and a control group of non-affected individuals, then sent them to Dr. Shomron's TAU lab.
Dr. Shomron and his fellow researchers applied a high-throughput technology to these samples, studying the microRNA of the olfactory neurons. Within these molecules, which help to regulate our genetic code, they were able to identify a microRNA which is highly elevated in those with schizophrenia, compared to individuals who do not have the disease.
"We were able to narrow down the microRNA to a differentially expressed set, and from there down to a specific microRNA which is elevated in individuals with the disease compared to healthy individuals," explains Dr. Shomron. Further research revealed that this particular microRNA controls genes associated with the generation of neurons.
In practice, material for biopsy could be collected through a quick and easy outpatient procedure, using a local anesthetic, says Dr. Shomron. And with microRNA profiling results ready in a matter of hours, this method could evolve into a relatively simple and accurate test to diagnose a very complicated illness.
Early detection, early intervention
Though there is much more to investigate, Dr. Shomron has high hopes for this diagnostic method. It's important to determine whether this alteration in microRNA expression begins before schizophrenic symptoms begin to exhibit themselves, or only after the disease fully develops, he says. If this change comes near the beginning of the timeline, it could be invaluable for early diagnostics. This would mean early intervention, better treatment, and possibly even the postponement of symptoms.
If, for example, a person has a family history of schizophrenia, this test could reveal whether they too suffer from the disease. And while such advanced warning doesn't mean a cure is on the horizon, it will help both patient and doctor identify and prepare for the challenges ahead.
###
American Friends of Tel Aviv University supports Israel's leading, most comprehensive and most sought-after center of higher learning. Independently ranked 94th among the world's top universities for the impact of its research, TAU's innovations and discoveries are cited more often by the global scientific community than all but 10 other universities.
Internationally recognized for the scope and groundbreaking nature of its research and scholarship, Tel Aviv University consistently produces work with profound implications for the future.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Contact: George Hunka ghunka@aftau.org 212-742-9070 American Friends of Tel Aviv University
Neurons in the nose could be the key to early, fast, and accurate diagnosis, says a Tel Aviv University researcher
A debilitating mental illness, schizophrenia can be difficult to diagnose. Because physiological evidence confirming the disease can only be gathered from the brain during an autopsy, mental health professionals have had to rely on a battery of psychological evaluations to diagnose their patients.
Now, Dr. Noam Shomron and Prof. Ruth Navon of Tel Aviv University's Sackler Faculty of Medicine, together with PhD student Eyal Mor from Dr. Shomron's lab and Prof. Akira Sawa of Johns Hopkins Hospital in Baltimore, Maryland, have discovered a method for physical diagnosis by collecting tissue from the nose through a simple biopsy. Surprisingly, collecting and sequencing neurons from the nose may lead to "more sure-fire" diagnostic capabilities than ever before, Dr. Shomron says.
This finding, which was reported in the journal Neurobiology of Disease, could not only lead to a more accurate diagnosis, it may also permit the crucial, early detection of the disease, giving rise to vastly improved treatment overall.
From the nose to diagnosis
Until now, biomarkers for schizophrenia had only been found in the neuron cells of the brain, which can't be collected before death. By that point it's obviously too late to do the patient any good, says Dr. Shomron. Instead, psychiatrists depend on psychological evaluations for diagnosis, including interviews with the patient and reports by family and friends.
For a solution to this diagnostic dilemma, the researchers turned to the olfactory system, which includes neurons located on the upper part of the inner nose. Researchers at Johns Hopkins University collected samples of olfactory neurons from patients diagnosed with schizophrenia and a control group of non-affected individuals, then sent them to Dr. Shomron's TAU lab.
Dr. Shomron and his fellow researchers applied a high-throughput technology to these samples, studying the microRNA of the olfactory neurons. Within these molecules, which help to regulate our genetic code, they were able to identify a microRNA which is highly elevated in those with schizophrenia, compared to individuals who do not have the disease.
"We were able to narrow down the microRNA to a differentially expressed set, and from there down to a specific microRNA which is elevated in individuals with the disease compared to healthy individuals," explains Dr. Shomron. Further research revealed that this particular microRNA controls genes associated with the generation of neurons.
In practice, material for biopsy could be collected through a quick and easy outpatient procedure, using a local anesthetic, says Dr. Shomron. And with microRNA profiling results ready in a matter of hours, this method could evolve into a relatively simple and accurate test to diagnose a very complicated illness.
Early detection, early intervention
Though there is much more to investigate, Dr. Shomron has high hopes for this diagnostic method. It's important to determine whether this alteration in microRNA expression begins before schizophrenic symptoms begin to exhibit themselves, or only after the disease fully develops, he says. If this change comes near the beginning of the timeline, it could be invaluable for early diagnostics. This would mean early intervention, better treatment, and possibly even the postponement of symptoms.
If, for example, a person has a family history of schizophrenia, this test could reveal whether they too suffer from the disease. And while such advanced warning doesn't mean a cure is on the horizon, it will help both patient and doctor identify and prepare for the challenges ahead.
###
American Friends of Tel Aviv University supports Israel's leading, most comprehensive and most sought-after center of higher learning. Independently ranked 94th among the world's top universities for the impact of its research, TAU's innovations and discoveries are cited more often by the global scientific community than all but 10 other universities.
Internationally recognized for the scope and groundbreaking nature of its research and scholarship, Tel Aviv University consistently produces work with profound implications for the future.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
There have been many attempts to integrate social media conversations with live TV, often through a "second screen" experience (basically, a smartphone app). But ABC News just announced something that I haven't seen before ? a mobile and web-based app called the Social Soundtracker. Maya Baratz, ABC News' head of new products, compared the app to the laugh tracks that accompany TV sitcoms, especially older ones. Most of us probably think that laugh tracks are fake and uncool, but Baratz said they addressed a real need ? people like to feel like they're watching TV with other people. That's also why there's so much conversation around TV shows on Facebook and Twitter, and that's what all these second screen/social TV startups have been trying to capture.
It is, according to North Carolina?s film community.
Advocates of the state?s film industry say a House bill that would change the way the state subsidizes film production would essentially drive the business away.
?You?d see productions just leaving North Carolina ? including ?Homeland,?? said Aaron Syrett, director of the North Carolina Film Office.
?Homeland? is the Emmy Award winning Showtime drama shot in Charlotte and about to enter its third season. It?s one of more than 40 projects that Syrett said resulted in $376 million worth of spending and thousands of jobs last year.
Critics of incentives ? which amounted to $45 million in 2012 ? say the money could be put to better use. And they point to a legislative study that found the credit itself is responsible for a fraction of the jobs the industry claims.
?It?s not worth it to deny $45 million to public education to help one industry,? said Rep. Paul Luebke, a Durham Democrat.
Luebke is co-sponsoring a bill that would eliminate the refundable portion of the state?s film tax credit. Production companies can now claim a 25 percent tax credit up to $20 million on productions spending more than $250,000 in qualified expenses.
The bill was sent to the House Rules Committee, often a virtual graveyard. But primary co-sponsors include two Republicans from the Wilmington area ? a major film production area ? as well as GOP Speaker Pro Tem, Paul Stam of Apex.
According to the Wilmington Star-News, hundreds gathered in the city last weekend for a rally opposing the bill.
The film council says there are currently three projects shooting in the Wilmington area and five in and around Charlotte. Syrett called Charlotte ?an emerging market? for film production.
At a meeting of the film council this week, vice chair E.A. Tod Thorne of Charlotte said a film producer who had planned to shoot in Charlotte was considering filming in Georgia because of the bill.
In a statement, Twentieth Century Fox Television, which produces ?Homeland,? said the proposed changes would be ?devastating? for the series, which is about to start filming its third season.
?We?ve grown to love the talent community (in Charlotte) and many of our key personnel have now made Charlotte their permanent home,? the statement said.
?We fear that reductions in, or elimination of, the state?s film incentives could have a devastating impact on our ability to continue to produce the show at the level of quality our viewers have come to expect.?
Apr. 24, 2013 ? Researchers from the U.S. Department of Energy's (DOE) SLAC National Accelerator Laboratory and Stanford University have designed a low-cost, long-life battery that could enable solar and wind energy to become major suppliers to the electrical grid.
"For solar and wind power to be used in a significant way, we need a battery made of economical materials that are easy to scale and still efficient," said Yi Cui, a Stanford associate professor of materials science and engineering and a member of the Stanford Institute for Materials and Energy Sciences, a SLAC/Stanford joint institute. "We believe our new battery may be the best yet designed to regulate the natural fluctuations of these alternative energies."
Cui and colleagues report their research results, some of the earliest supported by the DOE's new Joint Center for Energy Storage Research battery hub, in the May issue of Energy & Environmental Science.
Currently the electrical grid cannot tolerate large and sudden power fluctuations caused by wide swings in sunlight and wind. As solar and wind's combined contributions to an electrical grid approach 20 percent, energy storage systems must be available to smooth out the peaks and valleys of this "intermittent" power -- storing excess energy and discharging when input drops.
Among the most promising batteries for intermittent grid storage today are "flow" batteries, because it's relatively simple to scale their tanks, pumps and pipes to the sizes needed to handle large capacities of energy. The new flow battery developed by Cui's group has a simplified, less expensive design that presents a potentially viable solution for large-scale production.
Today's flow batteries pump two different liquids through an interaction chamber where dissolved molecules undergo chemical reactions that store or give up energy. The chamber contains a membrane that only allows ions not involved in reactions to pass between the liquids while keeping the active ions physically separated. This battery design has two major drawbacks: the high cost of liquids containing rare materials such as vanadium -- especially in the huge quantities needed for grid storage -- and the membrane, which is also very expensive and requires frequent maintenance.
The new Stanford/SLAC battery design uses only one stream of molecules and does not need a membrane at all. Its molecules mostly consist of the relatively inexpensive elements lithium and sulfur, which interact with a piece of lithium metal coated with a barrier that permits electrons to pass without degrading the metal. When discharging, the molecules, called lithium polysulfides, absorb lithium ions; when charging, they lose them back into the liquid. The entire molecular stream is dissolved in an organic solvent, which doesn't have the corrosion issues of water-based flow batteries.
"In initial lab tests, the new battery also retained excellent energy-storage performance through more than 2,000 charges and discharges, equivalent to more than 5.5 years of daily cycles," Cui said.
To demonstrate their concept, the researchers created a miniature system using simple glassware. Adding a lithium polysulfide solution to the flask immediately produces electricity that lights an LED.
A utility version of the new battery would be scaled up to store many megawatt-hours of energy.
In the future, Cui's group plans to make a laboratory-scale system to optimize its energy storage process and identify potential engineering issues, and to start discussions with potential hosts for a full-scale field-demonstration unit.
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The above story is reprinted from materials provided by DOE/SLAC National Accelerator Laboratory.
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Journal Reference:
Yuan Yang, Guangyuan Zheng, Yi Cui. A membrane-free lithium/polysulfide semi-liquid battery for large-scale energy storage. Energy & Environmental Science, 2013; DOI: 10.1039/C3EE00072A
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
By Mark Elkington MADRID, April 24 (Reuters) - Even Lionel Messi, so often Barcelona's saviour, was at a loss to explain how the La Liga leaders could come back from their Champions League semi-final mauling in Munich. Barca were thumped 4-0 away by an impressive Bayern Munich in their first leg on Tuesday, putting in one of their most toothless displays in recent memory. On Wednesday, they were greeted with newspaper headlines such as 'Historic beating' in Madrid-based daily Marca, 'Catastrophe' in Barcelona-based Mundo Deportivo, and 'Azulgrana Waterloo' in daily El Mundo. ...
DHAKA (Reuters) - A block housing garment factories and shops collapsed in Bangladesh on Wednesday, killing nearly 100 people and injuring more than a thousand, officials said.
Firefighters and troops dug frantically through the rubble at the eight-storey Rana Plaza building in Savar, 30 km (20 miles) outside Dhaka. Television showed young women workers, some apparently semi-conscious, being pulled out.
One fireman told Reuters about 2,000 people were in the building when the upper floors slammed down onto those below.
Bangladesh's booming garments industry has been plagued by fires and other accidents for years, despite a drive to improve safety standards. In November 112 workers died in a blaze at the Tazreen factory in a nearby suburb, putting a spotlight on global retailers which source clothes from Bangladesh.
"It looks like an earthquake has struck here," said one resident as he looked on at the chaotic scene of smashed concrete and ambulances making their way through the crowds of workers and wailing relatives.
Rescue workers try to rescue trapped garment workers in the Rana Plaza building which collapsed, in Savar, 30 km (19 miles) outside Dhaka April 24, 2013. A block housing garment factories and shops ... more? Rescue workers try to rescue trapped garment workers in the Rana Plaza building which collapsed, in Savar, 30 km (19 miles) outside Dhaka April 24, 2013. A block housing garment factories and shops collapsed in Bangladesh on Wednesday, killing nearly 100 people and injuring more than a thousand, officials said.REUTERS/Andrew Biraj (BANGLADESH - Tags: DISASTER BUSINESS) less? "I was at work on the third floor, and then suddenly I heard a deafening sound, but couldn't understand what was happening. I ran and was hit by something on my head," said factory worker Zohra Begum.
An official at a control room set up to provide information said 96 people were confirmed dead and more than 1,000 injured. Doctors at local hospitals said they were unable to cope with the number of victims brought in.
CRACKS IN BUILDING
Mohammad Asaduzzaman, in charge of the area's police station, said factory owners appeared to have ignored a warning not to allow their workers into the building after a crack was detected in the block on Tuesday.
Five garment factories - employing mostly women - were housed in the building, including Ether Tex Ltd., whose chairman said he was unaware of any warnings not to open the workshops.
"There was some crack at the second floor, but my factory was on the fifth floor," Muhammad Anisur Rahman told Reuters. "The owner of the building told our floor manager that it is not a problem and so you can open the factory."
He initially said that his firm had been sub-contracted to supply Wal-Mart Stores Inc, the world's largest retailer, and Europe's C&A. In a subsequent interview he said he had been referring to an order in the past, not current work.
Wal-Mart did not immediately respond to requests for comment. C&A said that, based on its best information, it had no contractual relationship with any of the production units in the building that collapsed.
The website of a company called New Wave, which had two factories in the building, listed 27 main buyers, including firms from Britain, Denmark, France, Germany, Spain, Ireland, Canada and the United States.
"It is dreadful that leading brands and governments continue to allow garment workers to die or suffer terrible disabling injuries in unsafe factories making clothes for Western nations' shoppers," Laia Blanch of the U.K. anti-poverty charity War on Want said in a statement.
November's factory fire raised questions about how much control Western brands have over their supply chains for clothes sourced from Bangladesh. Wages as low as $38.50 a month have helped propel the country to no. 2 in the ranks of apparel exporters.
It emerged later that a Wal-Mart supplier had subcontracted work to the Tazreen factory without authorization.
Buildings in the crowded city of Dhaka are sometimes erected without permission and many do not comply with construction regulations.
(Additional reporting by Andrew Biraj; Writing by John Chalmers; Editing by Andrew Roche)
?America?s Got Talent? fans can expect to see quite a few changes when the show returns next month. From its new location at Radio City Music Hall in New York, to the addition of judges Mel B and Heidi Klum, it promises to be ?bigger and better than any season" before -- at least that's what judge Howie Mandel said during a panel discussion at the NBC Summer Press Day on Monday.
But while changes are in store, returning judge Howard Stern wanted to make it clear to his new co-stars that one thing is going to stay the same.
?I?m the star of this show,? he said.
Stern was certainly the star of the panel discussion, playfully ribbing Klum for getting the lion?s share of the audience questions.
"(Host) Nick (Cannon) is married to Mariah Carey,? Stern told the audience. ?There are questions to be asked. I have about 50 of them! I'm only answering Heidi questions. Why don't you ask me what it's like to be a mom?"
After Klum explained how she managed to juggle the "AGT," in addition to her ?Project Runway? hosting duties and motherhood, Stern was ready with a few more zingers.
?You're gonna judge, but you're gonna be neglecting your children," he told her.? ?Something?s got to give. You're gonna bring the kids while we're doing the show? All, like, ten of them? That's gonna be fun.?
Klum (who, for the record, only has four kids) seemed unfazed by Stern?s jokes. The former model was eager to let the audience know what she would be bringing to the judging table.
"I feel like I've seen things all over the world,? she said. ?Being married to a musician for eight years, I've seen a lot of things, (and) I want to tell everyone how they're doing. I think it's part of my personality too."
In addition to the new four-judge format, "America's Got Talent" executive producer Sam Donnelly said that viewers will see other modifications this season.
"We're making some changes around the way we do storytelling,? she said. ?They're all subtle changes rather than actual big format ones. Generally it's a freshening up of how we tell stories, some backstage reality. We get to some of these guys (the judges) in more candid moments, which will be interesting. They don't know that yet."
One of the biggest changes will be how the judges' votes will work. With four judges on the panel rather than three, a contestant will now be required to get three ?yes? votes in order to move onto the next round.
?If there are two and two -- two people like the performance and two people don?t like it, that?s a no,? Mandel explained. ?You have to have three ?yes? votes to get through.?
?They?ve also given me complete veto power over the rest of the judges,? Stern teased. ?And I?m going to be topless. Everyone?s thrilled about that.?
While the new season of ?AGT? will be different than any before it, Stern sees no reason to alter the way he presents himself on the show.
?"I'm not bringing anything different,? he said. ?I'm an honest judge; you saw how good I was last season. I'm going to take these six- and seven-year-olds and make them cry!"
?America?s Got Talent? returns to NBC at 9 p.m. on June 4.
Are you looking forward to seeing the new judges in action? Share your thoughts on our Facebook page.
Dear THE BLACK (Progressive) Agenda Is Safe - Right Through These Doors
Dr Boyce Says: (5:25 mark)
Fight For Our Right To Have .......................A Good Education?
Fight For Our Right To Have........................A Job?
Fight For Our Right To ...............................Get Out Of Prison?
Sir - I do not consider you "ignorant and manipulative" like most of the "Embedded Black Fox Confidence Men" - but you are no less complicit.
WHY ARE YOU SURPRISED that the "Embedded Confidence Men" told "The Blacks" that THEIR VOTES ARE GOING TO BE STOLEN - during the run up to the "Presidential Election Of 2012" - only to go back into "Obama Promotion Mode" today?
WHERE WERE YOU?????..........................Telling The Masses Of Negroes That THE BLACK ATTORNEY GENERAL WOULD NEVER ALLOW Their Vote To Be Stolen? ?AND IF They Were Fearful That A POLICE MAN, STANDING IN FRONT OF THE POLLING PLACE Then They Probably Beat The Hell Out Of Some Member Of The Black Community - AND THE BLACK COMMUNITY DOESN'T NEED THEIR VOTE - Only THE DEMOCRATS AND PROGRESSIVE FUNDAMENTALISTS DO?
How Do You VOTE FOR YOUR SALVATION And Get A GOOD EDUCATION - Unless There Is A Dependency On SOME EXTERNAL FORCE OUTSIDE OF YOUR COMMUNITY?
How Do You VOTE FOR THE PRESIDENT OF THE NATION With The Hopes For A JOB That Is Near Your Community - Unless SOME ECONOMIC PRINCIPLE Of "Value Add" / "Supply And Demand" Is Molested? ?Does VOTING INCREASE THE MARKET VALUE That You Have To Offer Someone To EXCHANGE YOUR COMPETENCIES In Exchange For A SALARY - OR, Dr Watkins Are You Telling Us That THE NATION Should VALUE THE LABORER - By Spiking His SALARY Using $17 TRILLION DEBT MONEY? ?
Of Those "Mass Incarcerated" That You Speak Of - Arrested By OUT OF DATE LAWS - How Many Of The FAVORABLE LAW ENFORCEMENT OFFICIALS That The Black Community Has VOTED FOR With Pride - KEEP ARRESTING NEGROES Under These Same Statutes? ?IF OBAMA Can IGNORE THE "DEFENSE OF MARRIAGE ACT" BECAUSE HE SAYS THAT IT IS UNCONSTITUTIONAL - HOW MANY NEGROES HAVE TOLD THE LOCAL DA, POLICE CHIEF, Judge OR SHERIFF That The Voted For To NOT "MASS INCARCERATE ANY MORE YOUNG NEGROES" - Lest They Feel The WRATH Of The CONGREGATION?
WHY DIDN'T YOU STOP THE "CONFIDENCE SCHEME" IN 2012 WHEN IT COUNTED?
WHAT DID DR BOYCE WATKINS EXPECT AS THE "OPERATIONALZATION OF THE BLACK AGENDA" THAT WAS FRAUDULENT IN THE FIRST PLACE?
December 2012 - Yes I remember. ? "The Black Progressive Thought Leadership" went to Washington DC and did a number upon the "Black Community Development Consciousness" that as MORE DESTRUCTIVE than the "White Republicans in January 2009" went to the same restaurant to plot to make Obama a ONE TERM PRESIDENT.
The Republicans succeeded in RILING UP "THE BLACKS" - keeping them on the defensive, to ensure that they FAILED at their "racist scheme". In the mean time:
Africa was bombed by the US Government - but the Negro needed to be silent lest the Right Wing win
The American Negro - after 50 years of investments of his valuables in the scheme voiced by Bayard Rustin but expertly executed by Dr Ronald Daniels - STILL suffered from unemployment that was double that of his "Perfect 1.0 White Reference".
For the first time in American history - the US COMMANDER IN CHIEF was said to be a VICTIM OF RACISM - this despite the fact that he had full faith and confidence of the OFFICE -to impose any US Foreign Policy, Military, Or Economic Sanction upon ANY OTHER NATION - in the name of the United States - AND NOT GET ARRESTED for doing so
This so called "Black Leadership" convinced the "Americanized Negro" to fuse their BLACK COMMUNITY DEVELOPMENT CONSCIOUSNESS into the Oval Office.
Dear Sir - that "Quality Black Education" that you have vacated the local institutions and now look toward the White House to provide to you......................................
HERE IS YOUR QUALITY BLACK EDUCATION - THE "PROTECTORS OF BLACKNESS ARE HAPPY AND APPEASED" ...................................NOW YOU GET IT INSTANTIATED WITHIN THE BLACK COMMUNITY!!!!
He Became A Scholar By LOOKING INTO THE FAVORABLE PRESIDENT'S EYES
THE ANSWER TO YOUR CHALLENGE - DR BOYCE
EITHER you use your inside contacts to schedule every single Black male represented in this latest report with an individual session to TOUCH OBAMA'S HEAD and thus become A-STUDENTS...........................
OR YOU WORK TO PUT A STOP TO THIS FOOLISHNESS - DISALLOWING the "BLACK COMMUNITY DEVELOPMENT CONSCIOUSNESS" to be STOLEN INTO POLITICS - USING THE NEGRO BY TAKING HIS VALUABLES!!!!
LIMIT what "The Negro" EXPECTS to be addressed through VOTING and INSTEAD BE HONEST by telling him WHAT HE MUST DO MORE LOCALLY lest his pockets continue to get picked!!
Transworld Business Advisors Expands in Louisville Area. David Pierce, CPA, has opened an east end office at 10200 Forest Green Blvd., and Joseph MacDonald has joined the downtown office, 909 E. Market St.
Louisville, KY, April 22, 2013 - (PR.com) - Transworld Business Advisors, a national company that facilitates buying and selling businesses, is expanding their presence in Louisville.
David Pierce, CPA, has opened an east end office at 10200 Forest Green Blvd., and Joseph MacDonald has joined the downtown office, 909 E. Market St., as a registered representative and business adviser.
Maggie Harlow, owner of the Market St. office, said, ?With a more vibrant ? but still fluctuating ? economy and boomers seeking to reinvent their careers, we are finding increased interest in our services. The two Louisville offices are under separate ownership but we are working collaboratively to create a larger footprint in this area.?
Harlow said Transworld?s services include business brokerage, franchising, mergers and acquisitions. She pointed out that the company?s 200 brokers nationwide and 2,000 listings at any one time give local buyers and sellers a wide network of opportunity to make successful connections whether they want to list a business, franchise their current enterprise or buy a business or franchise operation.
David Pierce said, ?We are trained to help entrepreneurs find the ideal investment for their interests, talents and lifestyle. And, we advise sellers on the correct sales price and preparation of the necessary documentation. Then we become matchmakers and deal builders to market those businesses.?
Pierce said he feels uniquely qualified for his new venture after a career as a CPA with Price Waterhouse Coopers for 10 years, followed by 23 years with Porter Bancorp, Inc. where he served as CFO.
Joseph MacDonald of the downtown office worked for 15 years as the Metro Louisville development officer where he provided strategic leadership and business consulting services for companies of all sizes. He is a U.S. Army veteran officer.
?With our strong local team and our national network,? said Harlow, ?We are well positioned to serve our clients throughout the Louisville area and beyond.?
For more information about Transworld Business Advisors, visit www.tworld.com. The downtown office phone number is 502-649-4094; the east Louisville office number is 502-515-3341.
Transworld Business Advisors is a member of the United Franchise Group.
About United Franchise Group: The Global Leader for Entrepreneurs.
United Franchise Group (http://www.unitedfranchisegroup.com) is a $500-million franchising expert with 30 years of experience and 1,400 franchise locations in over 50 countries. Brands include SIGNARAMA, EmbroidMe, IZON Global Media, SuperGreen Solutions, Plan Ahead Events, and Transworld Business Advisors. Information on franchising opportunities is available at 800-286-8671 (U.S.) or 001-561-640-5570 (international).
Contact:
United Franchise Group Mary Mills 561-640-5570 www.unitedfranchisegroup.com
BAGA, Nigeria (AP) ? Fighting between Nigeria's military and Islamic extremists killed at least 185 people in a fishing community in the nation's far northeast, officials said Sunday, an attack that saw insurgents fire rocket-propelled grenades and soldiers spray machine-gun fire into neighborhoods filled with civilians.
The fighting in Baga began Friday and lasted for hours, sending people fleeing into the arid scrublands surrounding the community on Lake Chad. By Sunday, when government officials finally felt safe enough to see the destruction, homes, businesses and vehicles were burned throughout the area.
The assault marks a significant escalation in the long-running insurgency Nigeria faces in its predominantly Muslim north, with Boko Haram extremists mounting a coordinated assault on soldiers using military-grade weaponry. The killings also mark one of the deadliest incidents ever involving Boko Haram.
Authorities had found and buried at least 185 bodies as of Sunday afternoon, said Lawan Kole, a local government official in Baga. He spoke haltingly to Borno state Gov. Kashim Shettima in the Kanuri language of Nigeria's northeast, surrounded by still-frightened villagers.
Officials could not offer a breakdown of civilian casualties versus those of soldiers and extremist fighters. Many of the bodies had been burned beyond recognition in fires that razed whole sections of the town, residents said. Those killed were buried as soon as possible, following local Muslim tradition.
Brig. Gen. Austin Edokpaye, also on the visit, did not dispute the casualty figures. Edokpaye said Boko Haram extremists used heavy machine guns and rocket-propelled grenades in the assault, which began after soldiers surrounded a mosque they believed housed members of the radical Islamic extremist network Boko Haram. Extremists earlier had killed a military officer, the general said.
Edokpaye said extremists used civilians as human shields during the fighting ? implying that soldiers opened fire in neighborhoods where they knew civilians lived.
"When we reinforced and returned to the scene the terrorists came out with heavy firepower, including (rocket-propelled grenades), which usually has a conflagration effect," the general said.
However, local residents who spoke to an Associated Press journalist who accompanied the state officials said soldiers purposefully set the fires during the attack. Violence by security forces in the northeast targeting civilians has been widely documented by journalists and human rights activists. A similar raid in Maiduguri, Borno state's capital, in October after extremists killed a military officer saw soldiers kill at least 30 civilians and set fires across a neighborhood.
Sunday afternoon, the burned bodies of cattle and goats still filled the streets in Baga. Bullet holes marred burned buildings. Fearful residents of the town had begun packing to leave with their remaining family members before nightfall, despite Shettima trying to convince some to stay.
"Everyone has been in the bush since Friday night; we started returning back to town because the governor came to town today," grocer Bashir Isa said. "To get food to eat in the town now is a problem because even the markets are burnt. We are still picking corpses of women and children in the bush and creeks."
The Islamic insurgency in Nigeria grew out of a 2009 riot led by Boko Haram members in Maiduguri that ended in a military and police crackdown that killed some 700 people. The group's leader died in police custody in an apparent execution. From 2010 on, Islamic extremists have engaged in hit-and-run shootings and suicide bombings, attacks that have killed at least 1,548 people before Friday's attack, according to an AP count.
In January 2012, Boko Haram launched a coordinated attack in Kano, northern Nigeria's largest city, that killed at least 185 people as well. However, casualty numbers remain murky in Nigeria, where security and government officials often downplay figures.
Boko Haram, which means "Western education is sacrilege" in the Hausa language of Nigeria's north, has said it wants its imprisoned members freed and Nigeria to adopt strict Shariah law across the multiethnic nation of more than 160 million people. While the administration of President Goodluck Jonathan has started a committee to look at the idea of offering an amnesty deal to extremist fighters, Boko Haram's leader Abubakar Shekau has dismissed the idea out of hand in messages.
The Boko Haram network, which analysts and diplomats say has loose links to two other al-Qaida-aligned groups in Africa, has splintered into other groups as well. Its command-and-control structure also remains unclear. Recent Internet videos featuring Shekau have shown him with fighters carrying military weapons he said were stolen during attacks on Nigeria's military. Those weapons have included rocket-propelled grenades and other heavy weapons.
Fighters suspected to belong to Boko Haram also have been seen in northern Mali, where heavily armed Islamic extremists took power in the weeks following a military coup in that West African nation. Analysts also have worried that Boko Haram may get its hands on weapons smuggled out of Libya following its recent civil war.
Despite the deployment of more soldiers and police to northern Nigeria, the nation's weak central government has been unable to stop the killings. Meanwhile, violent atrocities committed by security forces against the local civilian population only fuels rage in the region.
___
Associated Press writer Jon Gambrell in Lagos, Nigeria, contributed to this report.
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FILE - In this March 13, 2013, file photo, New York Yankees shortstop Derek Jeter, left, and third baseman Kevin Youkilis talk before a spring training baseball game in Tampa, Fla. The Yankees said Thursday, April 18, 2013, that Jeter will be sidelined until after the All-Star break because of a new fracture in his injured left ankle. (AP Photo/Kathy Willens, File)
FILE - In this March 13, 2013, file photo, New York Yankees shortstop Derek Jeter, left, and third baseman Kevin Youkilis talk before a spring training baseball game in Tampa, Fla. The Yankees said Thursday, April 18, 2013, that Jeter will be sidelined until after the All-Star break because of a new fracture in his injured left ankle. (AP Photo/Kathy Willens, File)
FILE - In this March 9, 2013, file photo, New York Yankees shortstop Derek Jeter talks with trainer Steve Donohue after batting as the designated hitter in a spring training baseball game against the Altanta Braves in Tampa, Fla. The Yankees said Thursday, April 18, 2013, that Jeter will be sidelined until after the All-Star break because of a new fracture in his injured left ankle. (AP Photo/Kathy Willens, File)
FILE - In this March 13, 2013, file photo, New York Yankees shortstop Derek Jeter adjusts the laces on his glove before a spring training baseball game against the Philadelphia Phillies in Tampa, Fla. The Yankees said Thursday, April 18, 2013, that Jeter will be sidelined until after the All-Star break because of a new fracture in his injured left ankle. (AP Photo/Kathy Willens, File)
FILE - In this Oct. 14, 2012 file photo, New York Yankees shortstop Derek Jeter reacts after injuring himself in the 12th inning of Game 1 of the American League championship series against the Detroit Tigers in New York. Yankees captain Derek Jeter has left the team's minor league complex in Florida where he was rehabbing his injured ankle and gone for a medical exam. (AP Photo/Paul Sancya, File)
TAMPA, Fla. (AP) ? Not wearing a boot and walking without a limp, Derek Jeter spent 45 minutes at the Yankees' training complex Friday while he awaits more rehab for another ankle injury.
The 38-year-old shortstop was wearing sneakers when he left the minor league facility, where he talked with the training staff. When asked about his disappointment, he said: "Of course."
Jeter plans to fully address his latest injury in New York next week when the Yankees return from a road trip that ends Wednesday night at Tampa Bay.
The New York captain learned Thursday he had fractured his left ankle for a second time in six months. The team expects Jeter to resume rehab when the new crack heals, in four to eight weeks. Surgery will not be required. He is expected to return after the All-Star break.
Jeter was hurt last Oct. 13 in the AL championship series opener against Detroit. He was limited to five spring training games and 11 at-bats. When the team left spring training he stayed behind for rehabilitation in Tampa.
After three straight days of workouts, Jeter went to Charlotte, N.C., and was examined Thursday by Dr. Robert Anderson, who operated on him last Oct. 20. Jeter said he will have a follow-up visit with Anderson.
Yankees general manager Brian Cashman has repeatedly maintained the 13-time All-Star should be able to return to his previous level of play.
"Clearly he hasn't done anything wrong," he said. "He was cleared to play."
Cashman stressed this is "a new fracture, but a small one. That's, I guess, the only good part. They kept saying the word 'small.'"
Jeter is among four regulars missing from the Yankees' lineup, a group that totals 32 All-Star appearances. The defending AL East champions are 8-6 after Thursday's loss.
Outfielder Curtis Granderson broke his right forearm when hit by a pitch from Toronto's J.A. Happ in his first at-bat of spring training on Feb. 24 and is expected back next month. When asked Friday when he will be able to start swinging a bat, he said, "hopefully soon."
Richard Whalley, a 25-year-old CEO of a company that makes medical devices for diabetics, got a frantic phone call from his older brother right after the Boston Marathon bombings. He had seen a photo on Reddit of his bloodied father being carried away in a wheelchair.
The Boston Globe/Associated Press photo had quickly gone around the world.
But when the brothers called around to hospitals, there was no record of their parents, Ann and Eric Whalley, both 65 and recently retired. In the chaos that brought 175 victims to Boston-area hospitals, the couple had been registered under the wrong names.
"There was a possibility my mom was dead," said Whalley, who lives in Cambridge, Mass. "I knew she was older and pretty close to the blast."
COMPLETE COVERAGE: Boston Marathon Explosion
Whalley immediately posted a message on his Facebook page: "This is my dad in the picture in this link: I have no idea where my mum is. They were both bombed. I'm trying to figure out what hospital they are at. Can you help?"
And help they did. Within 10 minutes Facebook friends -- and friends of friends -- made calls to each hospital and found his parents at two different medical centers. Ann Whalley was at Brigham and Women's Faulkner campus at Harvard Medical School; Eric Whalley was at the Longwood campus in Jamaica Plain.
David L. Ryan/The Boston Globe/AP Photo
Boston Marathon Bombing a 'Mangled Mess': Witness Watch Video Runner Recounts 'Helpless Feeling' at Seeing 'Horrific Injuries' Watch Video
"It was amazing," said Whalley, who talked to ABCNews.com early today after just three hours sleep last night. "Multiple people called the hospitals. The third time they got a call [at Brigham and Women's] they decided to double check the records."
"They got hit pretty bad," he said.
Brigham and Women's Hospital has treated a total of 35 patients related to Monday's explosions. Ten patients remain in the hospital and four are listed in critical condition.
The Whalleys, who are hikers and like to walk around the city, were at the marathon finish line when the bombs exploded.
In the last three days, the couple has had nearly a dozen surgeries between them to remove multiple ball bearings and nails. Eric Whalley was hit in the skull and eye and may lose his sight and perhaps have brain damage. Ann Whalley got hit in the legs and has a badly mangled right foot.
"They were just there to see the action," said their son. "They did last year, as well. They were both runners and are pretty active for their age."
Just yesterday, his mother was moved to the Longwood campus on the same ward as his father, making life easier for the brothers. The hospital gave the Whalley brothers an apartment so they can be close to their parents.
His brother Chris, 34, lives in Salisbury, Mass., close to the New Hampshire border.
"My Dad had multiple surgeries but they are monitoring him closely to make sure everything has stabilized," he said.
His father had a blood clot on one side of his brain. He also had orthopedic surgery on his right leg. "The feet are in especially bad shape," said Whalley. "Part of the right foot was blown off."
In 1990, his parents emigrated from England to Colorado and eventually got U.S. citizenship. They moved to Charlestown, Mass., in 1998. A former professor of pharmacology, Eric Whalley had just retired from a job in biotechnology.
Just Wednesday night, Whalley had a conversation with his father, who gained consciousness for the first time.
"He was just barely talking, but he was understanding what we said," according to his son. "I told him his photo was on the front page of the Daily Mail [a newspaper in Britain.] He started laughing."
Fastest-Growing Paint and Sip Franchise Earns Top Industry Recognitions
HOUSTON - April 17, 2013 // PRNewswire // - Pinot's Palette, a national Paint and Sip franchise known for providing guests with an entertaining evening of art and wine, has kicked off 2013 by earning several commendations for its continued growth and success.
In March 2013, Pinot's Palette became the only Paint and Sip franchise included on Entrepreneur Magazine's Top New Franchises list. All companies included on the list were ranked according to financial strength, growth rate, and size, as well as other factors such as startup costs and percentage of terminations.
Company President Charles Willis notes that this is not the first time the company has been recognized by Entrepreneur Magazine.
"In January of this year, Pinot's Palette became the only Paint and Sip to receive an honorable mention on Entrepreneur's Franchise 500 list," Willis says. "It's very exciting to receive so much recognition from such an influential publication."
In addition to earning accolades from Entrepreneur Magazine, Pinot's Palette also won Franchise Business Review's Franchisee Satisfaction Award. The award, which was given out in February 2013, ranks companies solely on franchisee feedback. Pinot's Palette was ranked 11th on Franchise Business Review's list of Top 50 Franchises: Under 50 Locations.
Company CEO Craig Ceccanti says franchisee support is a key part of the Pinot's Palette business model.
"We have developed a wide variety of resources to help our franchisees every step of the way," Ceccanti says. "In fact, many of our franchisees tell us that they chose Pinot's Palette over other Paint and Sip franchises because we are the only one to offer such extensive training and support."
In addition to offering an intensive, week-long training "boot camp", the Pinot's Palette team helps new franchisees scout studio locations, negotiate leases, and build custom marketing plans based on local strategies. Additionally, all Pinot's Palette franchisees have access to the Pinot Technology Suite (PTS), a proprietary software system that streamlines all aspects of studio management.
"Our system makes it easier for franchisees to maintain an optimal work-life balance," Ceccanti says. "The PTS system helps them maximize sales, from point-of-sale transactions and reservation management to each location's website page."
Pinot's Palette offers both single and multi-unit development opportunities around the country. For more information, contact the company's headquarters office at Franchise@PinotsPalette.com or visit http://www.pinotspalette.com/Franchise.
About Pinot's Palette
Pinot's Palette is an upscale, entertainment-art studio that combines the appreciation of art and wine with step-by-step painting classes by an experienced local artist. The franchise - which began as a single, Houston-area studio in 2009 - now offers many studio locations throughout the United States and has become the fastest-growing Paint and Sip franchise in the country. For more information, visit www.PinotsPalette.com. (PRNewsFoto/Pinot's Palette)
Contact:
Mari Sokolowski 1-713-965-7996 mari@pinotspalette.com
FILE - In this Nov. 13, 2012 file photo, New York Knicks' Rasheed Wallace (36) dunks the ball in front of Orlando Magic's Glen Davis, left, during the first half of an NBA basketball game in Orlando, Fla. Wallace has retired again from the NBA after he was unable to recover from a left foot injury. The Knicks say in a statement that because of his injury Wallace "will not be available to play for us during the playoffs."(AP Photo/John Raoux, File)
FILE - In this Nov. 13, 2012 file photo, New York Knicks' Rasheed Wallace (36) dunks the ball in front of Orlando Magic's Glen Davis, left, during the first half of an NBA basketball game in Orlando, Fla. Wallace has retired again from the NBA after he was unable to recover from a left foot injury. The Knicks say in a statement that because of his injury Wallace "will not be available to play for us during the playoffs."(AP Photo/John Raoux, File)
GREENBURGH, N.Y. (AP) ? New York Knicks forward Rasheed Wallace retired again from the NBA on Wednesday after he was unable to recover from a left foot injury.
Shortly after coach Mike Woodson said Wallace was still struggling with soreness, the Knicks made the announcement in a press release.
"Rasheed has given this team everything he had," Woodson said in the statement. "He is a winner, true professional and leader on and off the court. Due to his injury, he will not be available to play for us during the playoffs. We owe this season's success to veterans like Rasheed."
It's a damaging blow for the Knicks, who loaded up on veteran big men this season but have now lost two of them for good in Kurt Thomas and Wallace, and have gotten almost nothing from Marcus Camby.
Also, Amare Stoudemire's status for the postseason is unclear as he recovers from right knee surgery.
The Knicks added another big man Wednesday by signing Earl Barron.
Wallace, 38, ended a two-year retirement this season to join the Knicks and play for Woodson, who was an assistant in Detroit when Wallace helped the Pistons win the 2004 NBA title. The 6-foot-11 forward was a key player off the bench during the Knicks' strong start, but hadn't played since December before returning Monday against Charlotte.
Wallace, who had surgery to repair a broken left foot on Feb. 28, lasted only 4 minutes before exiting because of continued soreness.
Woodson said during the Knicks' morning shootaround that Wallace was still bothered by pain and it wasn't known if he would be able to play Saturday against Boston in the postseason opener.
"Again, it's not my foot, so I don't know," Woodson said. "I mean, as long as I've known him, he's had a high tolerance for pain, but obviously it's bothering him and we're going to have to be cautious of that."
The Knicks expect Tyson Chandler (bulging disk) and Kenyon Martin (sprained left ankle) to be ready for the opener.
Thomas was waived recently to free up a roster spot after his season ended because of a stress fracture in his foot. The Knicks were hoping Wallace would be able to give them a few minutes a game in the postseason, but Woodson acknowledged earlier Wednesday that the soreness was a "big problem."
"Again guys, I'm not a doctor and I've never had foot problems, so I can't even begin to relate to what these cats are going through. But only thing (is) I feel for them, because I do know that they do want to be on the floor," Woodson said. "They feel like that they can help us and right now that's not the case with Rasheed."
Wallace retired after helping the Celtics reach the 2010 NBA Finals. Woodson reached out to him in the offseason about a comeback, seeking Wallace's defensive toughness and veteran leadership. But Wallace could only deliver it for 21 games in his 15th season, averaging 7.0 points and 4.0 rebounds in about 14 minutes per game.
Woodson said Carmelo Anthony, J.R. Smith and Jason Kidd also won't play Wednesday in the regular-season finale against Atlanta. He added that Quentin Richardson, who was signed Tuesday, could play significant minutes with the Knicks so short-handed.
Apr. 17, 2013 ? Salt Lake Valley, home to the Salt Lake City segment of the Wasatch fault zone and the West Valley fault zone, has been the site of repeated surface-faulting earthquakes (of about magnitude 6.5 to 7). New research trenches in the area are helping geologists and seismologists untangle how this complex fault system ruptures and will aid in forecasting future earthquakes in the area.
At the annual meeting of the Seismological Society of America (SSA), Christopher DuRoss and Michael Hylland of the Utah Geological Survey will present research today that indicates geologically recent large earthquakes on the West Valley fault zone likely occurred with (or were triggered by) fault movement on the Salt Lake City segment. DuRoss and Hylland consider it less likely that West Valley fault movement happens completely independently from movement on the Salt Lake City segment. This likely pairing has implications for how the seismic hazard in Salt Lake Valley is modeled.
The trenches have also helped the researchers revise the history of large earthquakes in the area, showing that the Salt Lake City segment has been more active than previously thought. Since about 14,000 years ago, eight quakes have occurred on the segment. Depending on the time period, these quakes have occurred roughly every 1300 to 1500 years on average. It has been 1400 years since the most recent large earthquake on the segment. The earthquake history of the West Valley fault zone had been largely unknown, but now four earthquakes have been well dated.
This new fault research contributes to a broader goal of evaluating Utah's earthquake hazards and risk. For example, this type of information on prehistoric earthquakes will be used by the Working Group on Utah Earthquake Probabilities, formed under the auspices of the Utah Geological Survey and U.S. Geological Survey, to forecast probabilities for future earthquakes in the Wasatch Front region.
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Public release date: 29-Apr-2013
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There have been many attempts to integrate social media conversations with live TV, often through a "second screen" experience (basically, a smartphone app). But ABC News just announced something that I haven't seen before ? a mobile and web-based app called 
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